ABSTRACT
Objective To evaluate the risk model of patients with secondary end stage renal disease (ESRD),and to validate its applicability by collecting clinical parameters of contrast induced nephropathy (CIN).Methods CIN patients were continuously enrolled in the study.The clinical data and laboratory results were analyzed.Eighteen months follow-up was performed for CIN patients to confirm the prognosis,and the long-term risk prediction and related risk assessment were analyzed based on the follow-up results.Results Totally 215 cases of CIN patients were included in the study.Among them,14 patients were lost in follow-up,and 19 patients progressed to ESRD stage during follow-up period.Cox regression analysis showed that the risk factors of poor prognosis in CIN patients included repeated angiography,high MRS scale score,high uKIM-1 level,high umAlb level and high uNGAL level.All of these factors were independent risk factors of ESRD within 18 months in CIN patients.Taking umAlb=36.80 ng/ml,uNGAL=128.21 ng/ml,uKIM-1=137.56 pg/ml as threshold,the areas under ROC curve were 0.746,0.756 and 0.768 respectively.Conclusion In this study,the risk factors of ESRD in CIN patients were predicted and quantified,and the CIN diagnosis and treatment system were further improved.